kuten tästä artikkelista näkee, vahvemmalla painetuissa kohdissa mainitaan että statiineilla hoitavien lääkäreiden tulee huomioida niiden myotoksisuus. ja toisaalta vielä 2005 aikaan myopatiaa aiheuttama mekanimsi ei ollut edes täysin selvitettynä. Hoidossa kehoitetaan käyttämään mahdollisimman matalaa annsota. myopatian varhaisen havaitsemisen tärkeyttä painotetaqan. Kriittinen tekijä vakavien seuraamusten estämiseksi on keskeyttää statiinihoito.
J Ren Nutr. 2005 Jan;15(1):87-93.The myopathy of statins.
Smogorzewski M.Source
Division
of Nephrology, Department of Medicine, Keck School of Medicine,
University of Southern California, Los Angeles, CA 90033, USA.
smogorze@usc.edu
Abstract
Statins
are first-line drugs for prevention and treatment of
hypercholesterolemia and atherosclerotic disease. Despite the fact that
statins are generally well tolerated and have a positive impact on human
health, their myotoxic properties should keep physicians on alert.
Mechanisms of statin-induced myopathy are still not fully understood.
Phenotypic characteristics of patients, individual statin properties,
and metabolic interaction with other drugs are important factors that
may increase risk for statin myopathy. The lowest effective dose of
statin should be used during treatment. Early recognition of myopathy
and discontinuation of statin is critical in preventing serious sequelae
such as rhabdomyolysis with all its complications.
- PMID:
- 15648014
- [PubMed - indexed for MEDLINE]
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