K-vitamiini ja nivelreuma

 Nivelreuma potilailla tämän tutkimuksen mukaan merkitsijät K-vitamiinista ja  K-vitamiinivajeesta osoittivat seuraavaa:
K-vitamiini vajetta merkitsevä  ucOC ( alikarboksyloitunut osteokalsiini)  oli koholla, myös  matrixmetalloproteinaasi 3 koholla.
Sen sijaan varsinainen  K-vitamiini itse,  menakinonilajit  MK-4, MK-7 ja  fyllokinoni (PK) olivat seerumipitoisuuksiltaan alentuneet,.
joten näiden kahden indikaattoriryhmän korrelaatio keskenään oli käänteinen.
Vitamiini K:n homologeja   voitaneen käyttää nivelreuman aktiivisuuden merkitsijöinä.

LÄHDE: https://www.ncbi.nlm.nih.gov/pubmed/27722902

J Bone Miner Metab. 2016 Oct 8. [Epub ahead of print]

Vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis.

Khojah HM¹, Ahmed S², Abdel-Rahman MS^3,4, Alkhalil KM⁵, Hamza AB⁵.

Abstract

The aim of this study was to evaluate the possible role of vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis (RA). In this study, 42 patients with RA and 40 healthy controls were enrolled. Serum levels of vitamin K homologs were measured using a high-performance liquid chromatography-fluorescence method. Different biochemical and clinical markers for disease activity were measured and correlated with serum levels of vitamin K homologs. There were no significant differences between RA patients and healthy subjects in demographic data. Patients with RA showed significantly higher levels of biochemical markers compared with healthy subjects (p < 0.001). These markers included rheumatoid factor (RF), anticyclic citrullinated polypeptide (anti-CCP), undercarboxylated osteocalcin (ucOC), matrix metalloproteinase (MMP-3), C-reactive protein (CRP), and disease activity score assessing 28 joints with erythrocyte sedimentation rate (DAS28-ESR). In addition, serum levels of vitamin K homologs were reduced in RA patients, and the levels of menaquinone-4 (MK-4) and menaquinone-7 (MK-7) were moderately to strongly inversely correlated with the clinical articular features in RA patients, whereas phylloquinone (PK) levels were weakly correlated. Serum levels of MK-4, MK-7 and PK were strongly inversely correlated with ucOC, MMP-3 and DAS28-ESR in RA patients. In contrast, serum levels of MK-4, MK-7 and PK were weakly correlated with CRP, RF and anti-CCP. These results suggest that serum levels of vitamin K homologs may be considered as potential biomarkers for disease activity. In addition, the results confirm the role of vitamin K deficiency in the etiology of RA.

KEYWORDS:
Biomarkers; DAS28-ESR; Matrix metalloproteinase; Rheumatoid arthritis; Vitamin K homologs

PMID:

27722902

DOI:

10.1007/s00774-016-0785-4

[PubMed - as supplied by publisher]

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